Pontotoc is located in northeast Mississippi about 20 miles west of Tupelo and about 15 miles northwest of the Natchez Trace Parkway. If traveling north on the parkway, exit at milepost 246 onto Mississippi Highway 41 and travel north 15 miles to Pontotoc. If traveling south on the parkway, exit at milepost 257 onto Mississippi Highway 76 (Pontotoc Parkway) and travel west 20 miles to Pontotoc.