Houston, Mississippi, one of two county seats of Chickasaw County, is located 30 miles southwest of Tupelo and five miles west of the Natchez Trace Parkway.
The land on which Houston resides was donated to the city by Judge Joel Pinson on the condition that it would be named for Sam Houston, a childhood friend. The middle of town where the Chickasaw County Courthouse sits is called Pinson Square.
- The Carnegie Library located at 105 West Madison Street was the first Carnegie library built in the state of Mississippi.
- Houston hosts the annual spring and fall Mississippi Flywheel Festival in April and September.
- Jeff Busby, called the “Father of the Natchez Trace”, was from Houston. Mr. Busby, a US Senator, introduced legislation in the 1930s to establish the Natchez Trace Parkway.
- The new Tanglefoot Trail® "rails to trails" route is 43 miles long and connects Houston and New Albany. Bicyclists, walkers and joggers can enjoy the trail while visiting Houston.
The population of Houston was 3,623 at the 2010 census.